Advance Level Question

1. The envelope of which of the following viruses is derived from the host cell nucleus?
a. Paramyxoviruses
b. Retroviruses
c. Orthomyxoviruses
d. Herpesviruses

2. Pick up the correct statement about viruses.
a. They are neither living nor non living but transitional/midway between non livings and livings
b. They resemble the living organisms in the intracellular state and non living chemicals in the extracellular state.
c. They are obligate intracellular parasites at genetic level and reproduce inside the host only.
d. all are correct.

3. Which of the following is an example of rod-shaped viruses having their capsomeres arranged helically and not in the stacked ring?
a. Bateriophage M13
b. Bateriophage MV-L2
c. Bateriophage T2
d. Bateriophage T4

4. The lysogenic state is governed by the activity of the regulatory region of the lambda phage genomes; this region is termed as:-
a. immunity repressor
b. operon repressor
c. immunity operon
d. none of these

5. In cell culture, measles virus may lead to:-
a. nuclear pyknosis
b. transformation of cells
c. syncytium formation
d. rounding and aggregation of cells

6. Assertion: Interferons are a type of antibodies produced by body cells infected by bacteria.
Reason : Interferons stimulate inflammation at the site of injury.
a. If both Assertion and Reason are true and the Reason is the correct explanation of the Assertion
b. If both Assertion and Reason are true but the Reason is not the correct explanation of the Assertion
c. If Assertion is true but Reason is false
d. If both Assertion and Reason are false

7. Viruses largely lack metabolic machinery of their own to generate energy or to synthesize:-
a. carbohydrate
b. protein
c. alcohol
d. all of these

8. In structure and classification of viruses, find the WRONG STATEMENT:
a. Helical symmetry such as Othomyxo virus
b. The viruses contain protein and nuclic acid
c. Translation is the formation of protein
d. Transcription is the formation of protein

9. The following diseases are caused by enteroviruses EXCEPT ONE:
a. Pleurodynea
b. Glomerulonephritis
c. Paralysis
d. Pericarditis

10. Assertion. Severe Acute Respiratory Syndrome (SARS) originated in China.
Reason. China is the most populated country of the world
a. If both Assertion and Reason are true and the Reason is the correct explanation of the Assertion
b. If both Assertion and Reason are true but the Reason is not the correct explanation of the Assertion
c. If Assertion is true but Reason is false
d. If both Assertion and Reason are false

11. TMV was first virus to be purified and crystallised by an american microhioiogkst in 1935 for which Nobel Prize was awarded to him in 1946. He was:-
a. W. M. Stanley
b. Peyten Rous
c. Sumner
d. Andre Lwoft

12. The viral pathogenesis, Find the WRONG STATEMENT:-
a. Spread of virus in the body through different route e.g. Blood, Saliva
b. Humoral immunity but not cell mediated immunity
c. Inclusion bodies produced by viruses can be single or many D) In cytocidal infection, cell usually die
d. Several RNA viruses can cause persistent infection

13. The human diploid cell vaccine is used for prevention of:
a. Rabies
b. Varicella
c. Hepatitis
d. Yellow fever

14. The viral nucleocapsid is the combination of:-
a. capsid and spikes
b. envelope and capsid
c. genome and capsid
d. capsomere and genome

15. Which one of the following statements about viruses is correct ?
a. Viruses possess their own metabolic system
b. All viruses contain both RNA and DNA
c. Viruses are obligate parasites
d. Nucleic acid of viruses is known as capsid

16. The infected cells continue to reproduce themselves as well as the virus, and the mature virions are extruded from the cell surface continuously over a long period of time. This type of release mechanism is called a:-
a. productive infection
b. inductive infection
c. resultant infection
d. all of these

17. The following statements regarding HIV are true EXCEPT ONE:
a. It belongs to the family reteroviridae
b. It is an oncovirus
c. It is associated with the enzyme reverse transcriptase
d. The sexual route is the main mode of transmission

18. The sequence of nucleic acid in a variety of viruses and viral host, will find more similarities:-
a. among different viral hosts than among different viruses
b. among different viruses than between viruses and their hosts
c. among different viral hosts than between viruses and their hosts
d. between viruses and their hosts than among different viruses

19. Which of the following viruses has not been associated with human cancer?
a. Hepatitis C virus
b. Hepatitis B virus
c. Varicella-Zoster virus
d. Herpes simplex virus type 2

20. The following viruses are associated with congenital infection EXCEPT ONE:
a. Rubella virus
b. Parvovirus B-19
c. RSV
d. Varicella

21. The following statements about herpesviruses are true EXCEPT ONE:
a. All are morphologically identical
b. All are DNA-viruses
c. All remain latent inside the human body after primary infection
d. All cause vesicular rash

22. Which of the following disinfectant is effective against viruses?
a. Hydrogen peroxide
b. Hypochlorite
c. Formaldehyde
d. All of these

23. When a virus enters a cell but does not replicate immediately, the situation is called:-
a. lysogeny
b. fermentation
c. symbiosis
d. synergism

24. Usually viruses are separated into several large groups based primarily on:-
a. nature of the host
b. nucleic acid characteristics
c. capsid symmetry
d. diameter of the viroin or nucleocapsid

25. The following viruses can be transmitted sexually EXCEPT ONE:
a. HSV-2
b. HIV
c. Adeno
d. Rubella

26. Viruses are non living as:-
a. they have high specific gravity and can be crystallised
b. they lack Lipmann system to generate ATP
c. they donot show growth and own functional autonomy
d. all of the above.

27. Which among the followings is Largest virus ?
a. Pox virus
b. TMV
c. T-Phage
d. Citrus tristeza virus

28. Viruses are similar to Mycoplasma in:-
a. presence of cell wall
b. absence of cell wall
c. absence of nucleic acid
d. plaeomorphic in shape.

29. Which is correctly matched ?
a. Ligase — Breaking dna strand
b. Thyroxine — Adrenal
c. Rous sarcoma — Reverse transcriptase
d. Flame cells — Roundworms

30. Which of the following called virus as Contagium vivum fluidum, i.e., infectious living fluid?
a. WM Stanley
b. MW. Beijerinck
c. DJ Ivanowsky
d. Louis Pasteur

31. What kind of embryo is often used for viral assays?
a. Mouse
b. Cat
c. Rat
d. Chicken

32. A non-virulent phage virus is a virus, whose genetic material:-
a. gets incorporated into the genetic ma¬terial of the bacterial cell
b. gets incorporated into the genetic material of the bacterial cell and remain in¬active for a long time
c. is destroyed after entering the bacterial cell
d. causes immediate rupture of the bacteria! cell

33. All viruses are entirely:-
a. obligate parasites
b. obligate saprophyte
c. facultative parasites
d. non livings

34. Which statement is not true for viruses ?
a. Viruses can grow in dilute sugar syrups in warm weather
b. Viruses are made up of proteins and nucleic acid
c. Viruses can not use oxygen
d. Viruses can multiply in living cells.

35. Phylum Protophyta has been formed to Include:-
a. Viruses
b. Viruses, Bacteria, Blue green algae and Rickettsiae
c. Viruses and Bacteria
d. Viruses and Cyanobacteria.

36. The first step in infection of a host bacterial cells by a phage is:-
a. adsorption
b. absorption
c. penetration
d. replication

37. Enzyme neuraminidase is carried by which of the following viruses?
a. Epstein-Barr virus
b. Human immunodeficiency virus
c. Influenza virus
d. Adenovirus

38. The viral DNA is removed from the host's chromosomes and the lytic cycle occurs. The process is called:-
a. inductive infection
b. resultant induction
c. spontaneous induction
d. spontaneous infection

39. The latest view for the origin of viruses is :
a. these arose from bacteria as a result of the loss of cell wall, ribosome etc.
b. these arose from some bacteria which had developed a nucleus only
c. these have arisen from nucleic acid and protein found in primitive soup
d. these are modified plasmids which are infact the fragments of the nucleic acids of the host

40. The envelope of an enveloped virus is derived from:-
a. the mitochondrion of the cell
b. the cell membrane
c. the endoplasmic reticulum of the cell
d. none of these

41. All viruses are essentially made up of:-
a. RNA + proteins
b. RNA or DNA + proteins
c. RNA + non-histone proteins
d. nucleic acids and proteins

42. The statement true for virus is that:-
a. they are living organisms having their own metabolic system
b. they are larger than bacteria and killed by antibiotics
c. they have either DNA or RNA but no cytoplasm
d. they replicate in animal cells only and are facultative parasites.

43. Which of the following statements is not true of viruses?
a. Viruses have been successfully grown in pure cultures in test tubes
b. All viruses are obligatory intracellular parasites
c. All viruses have either DNA or RNA as their genetic material
d. Viruses probably arose from small fragments of cellular chromosomes

44. Which is correct:-
a. RNA is genetic material of bacteria
b. RNA is genetic material of all virus
c. DNA is genetic material of some organism
d. Some virus has RNA as genetic material

45. Minimum genes are found in:-
b. Polio virus
c. Vaccinia virus
d. foot and mouth disease virus

46. Which statement is incorrect ?
a. Plant viruses cotnain RNA
b. Animal viruses contain DNA
c. T4 contains double stranded DNA
d. TMV contains double stranded RNA

47. In the simplest capsid, there is a capsomere at each of the 12 vertices; this capsomere, which is surrounded by five other capsomeres, is termed a:-
a. penton
b. polyhedra
c. icosahedral
d. helical

48. The following viral diseases are characterized by maculopapular rash EXCEPT ONE:
a. Measles
b. Rubella
c. Exanthem subitum
d. Herpangina

49. The viral DNA of the temperate phage, instead of taking over the functions of the cell's genes, is incorporated into the host DNA and becomes a prophage in the bacterial chromosome, acting as a gene. This happens in:-
a. lysogeny
b. spontaneous induction
c. lytic phase
d. none of these

50. Viruses are living as:-
a. they can replicate and undergo muta¬tions and adaptations
b. they are destroyed by UV rays and X-rays
c. they have nucleic acid and show host specificity
d. all of the above

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